FREQUENCY OF HEPATITIS B VIRUS GENOTYPES IN HBsAg POSITIVE PATIENTS IN KHYBER PAKHTUNKHWA
Article Sidebar
Main Article Content
Abstract
Objective: To determine the different Hepatitis B Virus (HBV) genotypes in HBsAg positive patients .
Material and Methods: One hundred and forty three HBsAg positive patients were included in the study. All patients
were anti-HCV and anti-HIV negative. All the samples were confirmed for HBV DNA with Rotor GeneTM Real Time
Quantitative PCR while HBV DNA positive samples were subjected to type specific PCR for HBV genotyping (A-F).
Results: Of 143 samples, 107 (74.82%) were male and 36(25.17%) female, age ranged between 20-40 years. The
study demonstrated genotype D in 72 (50.34%) patients as the predominant genotype in KPK population. Genotype
B was observed in 37 (25.87%), genotype A in 24 (16.78%) and both genotypes B and D in 10 (6.99%) patients.
Genotype C, E and F were not found in any patient.
Conclusion: Our study has demonstrated a heterogeneous distribution of HBV genotypes. More extensive studies are
required to investigate genetic and geographical divergence and characteristics of the virus in Khyber Pakhtunkhwa (KP).
Article Details
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.