TY - JOUR AU - Ahmed, Nisar AU - Khitab, Nadia AU - Waheed, Rashid AU - Muslim, Muhammad AU - Maroof, Syed Asad AU - Aurangzeb, Mahmud AU - Ahmad, Mushtaq PY - 2018/03/01 Y2 - 2024/03/29 TI - COMPARISON OF EFFICACY OF LATERAL INTERNAL SPHINCTEROTOMY (LIS) VERSUS GLYCERYL TRINITRATE (GTN) IN THE TREATMENT OF CHRONIC ANAL FISSURE JF - Journal of Medical Sciences JA - JMS VL - 25 IS - 1 SE - Articles DO - UR - https://jmedsci.com/index.php/Jmedsci/article/view/78 SP - 45-48 AB - <p>Objectives: To determine the effectiveness of Glyceryl Trinitratepaste (GTN) versus Lateral Internal Sphincterotomy<br>(LIS) in treatment of chronic anal fissure in terms of pain relief and cessation of bleeding per rectum.<br>Material and Methods: This randomized control study was carried out in Surgical A Unit, Khyber Teaching Hospital,<br>Peshawar, Pakistan from May 2013 to April 2015. On the basis of convenient purposive sampling consecutive 110<br>patients with chronic anal fissure were selected from those came through outpatient department for anal pain and<br>bleeding per rectum. The patients were divided into 2 groups A (LIS) and B (GTN), by simple random sampling to<br>which either topical GTN treatment or surgery i.e. LIS were offered respectively, and were advised to follow up at 2nd<br>and 6th weeks. Patient’s symptoms were noted in proforma at each follow up.<br>Results: In group A in 98% patients the bleeding had stopped by 2 weeks and in 100% patients by 6 weeks postoperatively,<br>whereas in group B, the bleeding had stopped in 78% and 90% at 2 and 6 weeks respectively. The difference in<br>both groups was statistically significant. The mean pain scores in group A was 1.51±0.29(95% CI) compared to group<br>B as 3.93±0.38(95% CI) at 2 weeks; and pain scores of group A was 0.35±0.16(95% CI) as compared to group B as<br>2.11±0.37(95% CI). The difference in both groups was statistically significant.<br>Conclusion: Lateral Internal Sphincterotomy is the quick and effective method of management for chronic anal fissure<br>regarding improvement of symptoms as compared to medical treatment with Glyceryl Trinitrate treatment.</p> ER -