EFFICACY OF ONDANSETRON AND METOCLOPRAMIDE AGAINST POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

Abstract

Objectives: Comparing the clinical efficacy of the antiemetics (Ondansetron and Metoclopramide) in preventing postoperative
nausea and vomiting (PONV) in patients undergoing Laparoscopic Cholecystectomy (LC).
Material and Methods: This is a randomised study conducted at anesthesiology department, Khyber Teaching Hospital,
Peshawar, Pakistan from April 2015 to December 2015. Two treatment arms Group A (Ondansetron) and B (Metoclopramide)
were created. A sample of 60 patients was selected in each treatment group.
Results: The overall mean age was 43.42 ± 10.8 years with 37 (30.8%) males and 83 (69.2%) females in a ratio of 1 to
2.24. Overall mean weight was 77.08 ± 9.05 Kg. Mean age in group A was 43.5 ± 10.8 years while it was 43.2 ± 10.9
years. Similarly, mean weight in group A was 76.5 ± 9.3 Kg while it was 77.6 ± 8.8 Kg. A Chi-squared test performed
for treatment group versus the incidence of PONV showed that PONV in group A was 13.3% while in group B it was
27.5% of the total episodes of PONV with a significant association of PONV with group B (p = 0.002). The early PONV
episodes occurred in significantly higher proportion in group B as compared to group A (15% group B versus 6.7%
in group A, p = 0.027). However, late PONV episodes were not significant for any treatment group (6.7% in group A
versus 13.3% in group B, p = 0.068).
Conclusion: Peri-induction use of intravenous ondansetron is an effective alternative than intravenous metoclopramide
in prevention of nausea/vomiting after LC.