SPECTRUM OF MORPHOLOGICAL CHANGES IN ERYTHEMA MULTIFORME
Article Sidebar
Main Article Content
Abstract
The spectrum of morphological changes in erythema multiforme
ABSTRACT
Introduction:
Erythema multiforme (EM) is a self-limiting, acute, immune-mediated condition. There is a long list of differential diagnosis which needs to be differentiated from the erythema multiforme e.g. pemphigus vulgaris, paraneoplastic pemphigus, mucosal bullous pemphigoid, and linear IgA dermatosis. In addition, primary herpetic infection, other viral diseases such as handfoot-mouth disease, erosive lichen planus, fixed drug eruption, lupus erythematosus, urticaria, cutaneous vasculitis, and some neutrophilic dermatoses have to be considered in the differential diagnosis of EM.
For diagnostic confirmation of EM and to differentiate it from other related disorders, in addition to the clinical information, histopathology, electron microscopy, immunofluorescence microscopy and even serological studies may be needed to be done.
Immunofluorescence and electron microscopy are expensive diagnostic modalities. Pakistan being developing country, it is not possible to have immunofluorescence and electron microscopyin each and every laboratory center of Pakistan, therefore the reliance of diagnosing erythema multifome on the basis of histopathological features becomes very important.
Objective:
To evaluate the histopathological changes in erythema multiforme
To determine the frequency of microscopic morphological changes in erythema multiforme.
Materials and methods
Setting:
The study will be conducted in the Pathology Department at KTH/KMC Peshawar.
Duration of Study:
January 2018 to January 2019.
Sample Size:
Total 34 cases
Sampling Technique:
Non probability purposive sampling
Study design:
Retrospective, chart review study
Sample Selection
Inclusion criteria:
- All age groups
- Both sexes
- All skin biopsy specimens diagnosed as Erythema multiforme
Exclusion criteria:
- Autolyzed tissue
- Relevant clinical history is not available
Data collection procedure:
The retrospective chart review study will be carried out in Pathology section KTH/KMC. In this study all cases of EM between 2018 and 2019 will be analyzed. The demographic profile (i.e. age, sex)The relevant history regarding nature, intensity and duration of the symptoms will be recorded if available.
The criteria for microscopic morphology will include epidermal and dermal changes. The epidermal changes to be studied during the research will include hyperkeratosis, epidermal necrosis, scab formation, acanthosis, hemorrhage and ulceration.
The dermal changes will include perivascular inflammation, granulation tissue, mucinous degeneration of collagen and fibrin thrombi.
The data will be recorded in anexcel sheet and then entered in SPSS computer software version 16.
Key words: Erythema Multiforme, histopathology morphological changes in EM, bullous diseases of skin
Article Details
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.