RESISTANCE TO FLUOROQUINOLONES AMONG MULTIDRUG RESISTANT ESCHERICHIA COLI FROM URINARY TRACT SPECIMENS OF DIABETIC PATIENTS

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Maria Khan
Fatima Zahra
Zufishan Batool
Shifa Basharat
Shazia Tariq
Tahir Ghafoor

Abstract

Objective: To analyze bacterial susceptibility of Escherichia coli isolated from urine samples of hospitalized diabetic
patients to fluoroquinolones.
Material and Methods: A total of four hundred and ten (410) isolates of Escherichia coli were studied from May-October
2018 at two teaching hospitals of Peshawar. Urine samples from Diabetic patients were generally enlist from internal
medicine, surgical wards and intensive care divisions. Primary susceptibility testing was performed in accordance with
Clinical and Laboratory Standard Institute (CLSI) guidelines. Results were interpreted as norfloxacin resistant if zone
diameter is ≤ 12 mm andciprofloxacin resistant for zone diameter ≤ 15 mm.
Results: Out of 410 isolates of Escherichia coli, 373(91%) were fluoroquinolones resistant and 37(9%) were fluoroquinolones
sensitive.
Conclusions: Fluoroquinolones resistance in Escherichia coli causing UTI is prevalent in our setup due to irrational use
of antibiotics. Appropriate antibiotic management strategies are needed to curtail the spread of this form of resistance.

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