GESTATIONAL TROPHOBLAST NEOPLASIA AND MORTALITY RISK FACTORS
Article Sidebar
Main Article Content
Abstract
Objective: To analyze the risk factors associated with mortality in patients receiving treatment for Gestational Trophoblast
Neoplasia (GTN).
Material and Methods: Rertospective, cross- sectional study done at Department of Obstetrics and Gynaecology,
Hayatabad Medical Complex, Peshawar, Pakistan, from June 2005 to June 2014. Ninety women with the diagnosis of
GTN were hospitalized and treated according to standard chemotherapeutic regimens. Hospital records of patients
demographic profile, age, parity, antecedent pregnancy, serum ?-hCG levels, site of metastasis, FIGO score, type of
chemotherapy, and treatment outcomes including mortality were studied. Data analysis done through SPSS 16.
Results: In 90 patients diagnosed with GTN, 59(65.6%) patients were low risk and 31(34.4 %) were in high risk category.
Nine out of 90 patients diagnosed with GTN died during initial treatment giving overall mortality of 10%. All patients
who died were in high risk category with stage IV GTN. Six out of nine patients had term pregnancy as antecedent
pregnancy. Five out of 9 patients that died had serum ?-hCG levels of >100000IU/ml. Eight out 9 patients had FIGO
scored between 9-12. Metastasis was present in all the patients that died. Three patients had metastasis present both
in Brain and Liver and two had metastasis only in liver, while other two had lung metastasis.
Conclusions: High FIGO score, high pretreatment serum ?-hCG levels, previous term pregnancy, liver and brain metastasis
have been associated with adverse outcome like mortality in patients with gestational trophoblast neoplasia:
a rare but highly curable malignancy.
Article Details
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.