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Objective: To determine the frequency of thyroid dysfunction in pregnant women with diabetes.
Material and Methods: This study was conducted at the Department of Obstetrics and Gynecology, Khyber Teaching
Hospital, Peshawar - Pakistan. The study design was descriptive cross sectional. 150 patients were observed during
the study and the duration of the study was from January 2016 to June 2016, after the approval of research topic from
research committee. The sample size was calculated using WHO formula using confidence level 95%, and margin of
error 5. Moreover, for sample collection consecutive sampling technique was used which is non-probability technique.
Results: Among 150 subjects 75 (50%) were gestational and 75 (50%) were pre gestational diabetes. Mean age was
33.1 ± 4.5 years. The mean duration of gestational amenorrhea was 27.03± SD 1.2. The mean gravidity and parity
was noted to be 3.9± SD 1.3 and 2.7 ± SD 1.2 respectively. Regarding biochemical profile mean random blood sugar
as 237.8 ± SD 28.7, mean TSH was 13.5 ± SD 5.1, mean serum free T4 was 2.9 ± SD 2.1. The most predominant
thyroid dysfunction was Subclinical Hypothyroidism when stratified according to age gravidity, parity, and gestational
Conclusion: The prevalence of thyroid dysfunction and specifically hypothyroidism is high with pre-gestational and
gestational diabetes mellitus in women. To reduce the maternal and fetal complications it is therefore essential to do
the screening and treatment of hypothyroidism in these patients.
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