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Objective: To study the efficacy, safety and maternal satisfaction of oral misoprostol for medical induction of labor in
patients with prelabour rupture of membrane at term (PROM).
Material and Methods: This descriptive study was carried out in the Obstetrics unit of Rehman Medical Institute, Peshawar-
Pakistan, from January 2015 to December 2018. A total of 546 admitted patients were selected for the study
in whom 50 microgram Misoprostol was administered orally at four hourly intervals. Labour was induced in selected
patients and post-delivery complications were recorded.
Results: The age range of patients was 25.19 years.±3.529 SD, Out of 546 gravid patients, Primigravida and multigravida
were 241 (44.1%) & 39(12.7%) respectively. There were more failed inductions in primigravida 71 (29.5%)
patients, as compared to multigravida 39(12.7%). 436(79.8%) of women had a successful vaginal delivery compared
to 110(20.1%) patients who failed IOL and underwent emergency caesarean section. The induction delivery interval
was longer in primigravida with only 105(34.1%) patients delivering within 24 hours, in contrast to multigravida with
126(52.2%) achieving a vaginal delivery within 24 hours of induction.
Conclusion: In patients with PROM at term, Oral Misoprostol dose of 50 microgram every 4 hours, is safe, cheap, an
effective agent for cervical ripening, significantly reduces the PROM-delivery interval & associated with low rate of CS,
without adversely affecting maternal or fetal outcome.
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