SERUM SELENIUM LEVELS IN SELECTED TYPES OF PSORIASIS PATIENTS IN PAKISTAN

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Shahnaz Dilawar
Afzal Shah
Zahoor Ahmad

Abstract

Objectives: To estimate the micronutrient selenium level in the a serum samples a of a the psoriatic patients of both
genders from different areas of Pakistan.
Material and Methods: The serum samples were collected from patients and healthy subjects of same.age and gender
groups for comparative study. Serum samples were oxidized by 60% nitric, acid and 70% hypochloric acid”The serum
selenium (Se) concentration was measured using HGAAS (hydride generation atomic absorption spectrophotometerHS-
55 batch system). Mean ±SD of serum Se levels (μg/L) were 82 ±1.8 and 108 ±1.3 in patients and controls
respectively. T-test and One-Way ANOVA were applied. This case control study was carried out in Bannu university of
science and technology Pakistan with the collaboration of Govt. Sifwat Ghayur Shaheed memorial children hospital
Peshawar Pakistan, NIH(National institute of medical sciences) and National Physical Standard Laboratory PCSIR
Islamabad from April 2013 to April 2015.
Results: In psoriatic patients serum Se level was significantly lower than that of healthy controls (P<0.001). The result
of the study revealed that 480 (98%) of the psoriatic patients have low serum se compared with 100 control. The type of
psoriasis may have an effect on serum Se.The lower serum Se is found in pustul psorisis followed by” Erythrodermic,
Scalp, Guttate and plaque” psoriasis.
Conclusion: Selenium deficiency can contribute in the pathologic process of psoriasis.”

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