NEW EMERGING PATTERN OF SENSITIVITY OF SALMONELLA TYPHI: A SINGLE CENTRE EXPERIENCE.

Main Article Content

Naveed Iqbal
Muhammad Abdur Rahman Afridi
Muhammad Bilal Awan
Atiqullah
Ilyas Muhammad

Abstract

NEW EMERGING PATTERN OF SENSITIVTIY OF SALMONELLA TYPHI: A SINGLE CENTRE EXPERIENCE.


 ABSTRACT


Objective: To determine the current sensitivity patterns of Salmonella typhi in population of Khyber Pakhtunkhwa province of Pakistan.


Materials and methods: This descriptive observational study was conducted in Lady Reading Hospital, Peshawar, Pakistan. A total of 388 blood culture proven salmonella typhi patients were included in the study. All samples reported salmonella typhi. MDR-typhoid defined as resistance to three first-line antibiotics (chloramphenicol, ampicillin and cotrimoxazole) used to treat typhoid fever. XDR-typhoid defined as resistance to the three first-line drugs as well as quinolones plus third-generation cephalosporins.


Results: Among the total of 388 patients, 245(63%) were male and 143(37%) were female. The mean age was 28.61±14.87 years. Fever was the predominant symptom (99.5%), affecting mainly young patients (84%). Salmonella typhi showed 100% sensitivity to Imipenem and Meropenem, and 92% to azithromycin. S. typhi showed 95% resistance to ciprofloxacin, 92% to cefixime and 86% to ceftriaxone. Multidrug-resistant (MDR) S. typhi was found in around 91.4% of blood cultures, whereas extended-drug-resistant (XDR) S. typhi was isolated from 91% cultures.


Conclusion: Our study showed high percentage of XDR and MDR Salmonella typhi which is an alarming situation, especially in younger population of the province.


 

Article Details

How to Cite
Iqbal, N., Afridi, M. A. R., Awan, M. B., Atiqullah, & Muhammad, I. (2024). NEW EMERGING PATTERN OF SENSITIVITY OF SALMONELLA TYPHI: A SINGLE CENTRE EXPERIENCE. Journal of Medical Sciences, 32(2), 185–189. https://doi.org/10.52764/jms.24.32.2.13
Section
Articles