COMPARISON OF SENSITIVITY OF BLOOD CULTURE, C-REACTIVE PROTEIN, AND ARTERIAL BLOOD GASES IN EARLY NEONATAL SEPSIS IN A TERTIARY CARE CENTRE, PESHAWAR
Article Sidebar
Main Article Content
Abstract
Objectives: To determine the sensitivity of serum levels of C-reactive protein (CRP) and arterial blood gases (ABGs) along with blood culture in the diagnosis of early-onset neonatal sepsis.
Material and methods: This cross-sectional study was conducted at the Department of Pediatrics, Town Women and Children Hospital, Peshawar, from March 2020 to March 2023. A total of 215 neonates diagnosed with Early onset neonatal sepsis were included in the study. Full blood count, arterial blood gases, blood culture, and C-reactive protein were determined and assessed for diagnostic utility.
Results: Amongst the 215 neonates, the mean age was 5±2 days. There were 131 (61%) males and 84 (39%) females, with a male-to-female ratio of 1.1 to 0.7. Blood cultures were positive in 77 (36%) and negative in 138 (64%) cases. Arterial blood gases were abnormal in 180 (83%) cases and negative in 35 (17%) cases. Using the standard CRP cut-off value of 5 mg/dl, C-reactive protein was positive in 191 (88%) cases and negative in 24 (12%) cases. Sensitivity for blood culture, arterial blood gases, and C-reactive protein were 35%, 83%, and 88% respectively.
Conclusion: C-reactive protein and arterial blood gases are more sensitive for accurate and timely diagnosis of Early Onset Neonatal Sepsis in a resource restraint setup.
Keywords: Arterial blood gases, Blood culture, C-Reactive Protein, Early Onset Neonatal Sepsis, Mean platelet volume.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.
