MULTI-DRUG RESISTANT ESCHERICHIA COLI AND THEIR SENSITIVITY TO ORAL FOSFOMYCIN IN URINARY TRACT INFECTIONS: A SINGLE-CENTER EXPERIENCE

Main Article Content

Iqbal Haider
SanaUllah
Kalsoom Bibi
Hammad Naeem
Hamza Ali
Wazir Muhammad

Abstract

Objectives: To determine the frequency of Escherichia coli (E. Coli) with multi-drug resistance and sensitivity to oral Fosfomycin in urinary tract infections in a public sector hospital of Peshawar Pakistan.


Material and Methods: A descriptive cross-sectional study with a convenient consecutive sampling technique at the Department of Medicine Khyber Teaching Hospital Peshawar. A total of 179 patients were recruited in the current study. Detailed history and examination were carried out followed by routine baseline investigations. Under rigorous aseptic settings, two clean midstream urine samples from patients exhibiting symptoms of a urinary tract infection were collected. These samples were then promptly transferred to the hospital laboratory for routine evaluation and E.Coli inoculation on culture media. Once E.Coli was detected, it was tested for antibiotic sensitivity and resistance against the antibiotics mentioned. The multi-drug resistant (MDR) strains were isolated and their sensitivity was checked against oral fosfomycin. All the variables of data were recorded in SPSS version 20. Descriptive and inferential statistics will be utilized to elaborate study findings.  


Results: The mean age in this study was 37 years with a standard deviation was ±11.27.
Seventy-three (41%) patients were males and 106 (59%) patients were females. One hundred and eleven (62%) patients had multidrug-resistant E.Coli among which oral Fosfomycin was sensitive in 108(97%) patients and was resistant in 3(3%) patients presenting with urinary tract infection.


Conclusion: The multidrug-resistant E. coli strains are common in our setup. However, oral fosfomycin has documented sensitivity against these MDR strains of E. coli in the majority of UTI cases. 


Keywords: Multidrug-resistant Escherichia coli, Drug Sensitivity, Fosfomycin, urinary tract infection

Article Details

How to Cite
Haider, I., Sana Ullah, Kalsoom Bibi, Hammad Naeem, Hamza Ali Khan, & Wazir Mohammad Khan. (2023). MULTI-DRUG RESISTANT ESCHERICHIA COLI AND THEIR SENSITIVITY TO ORAL FOSFOMYCIN IN URINARY TRACT INFECTIONS: A SINGLE-CENTER EXPERIENCE. Journal of Medical Sciences, 31(02), 97–101. https://doi.org/10.52764/jms.23.31.2.1
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Author Biographies

Iqbal Haider, Khyber Medical College, Peshawar

Associate Professor

Department of Medicine

MTI KTH/KMC Peshawar

SanaUllah , Department of Medicine Khyber Teaching Hospital Peshawar

Post Grauate Trainee 

Department of Medicine MTI KTH Peshawar

Kalsoom Bibi, Department of Gynae and Obstetrics Khyber Teaching Hospital Peshawar

Consultant Gynaecologist 

Hammad Naeem, Department of Medicine Khyber Teaching Hospital Peshawar

Post Graduate Trainee 

Department of Medicine

MTI KTH Peshawar

Hamza Ali, Department of Medicine Khyber Teaching Hospital Peshawar

Assistant Professor 

Department of Medicine

MTI KTH/KMC Peshawar

Wazir Muhammad, Department of Medicine Khyber Teaching Hospital Peshawar

Professor of Medicine

MTI KTH/KMC Peshawar

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