HISTOPATHOLOGICAL PATTERN IN PATIENTS WITH CLINICALLY SUSPECTED RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS

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Shah Muhammad
Muhammad Ikram
Akhtar Ali
Sartaj Alam
Khan Bahadur
Amer Azhar

Abstract

Objective: To analyze the histopathological patterns of renal diseases in patients who presented with clinically suspected
rapidly progressive glomerulonephritis (RPGN).
Material and Methods: This is a descriptive review of data of renal biopsies in patients with clinically suspected
RPGN, who underwent renal biopsy at Nephrology unit Lady Reading Hospital, Peshawar, Pakistan from July 2010 to
July 2016. All patients admitted to Nephrology unit with a clinical suspicion of RPGN and had renal biopsies done for
histological diagnosis.
Results: Tubulo-interstitial Nephritis (TIN) 38(39.5%) was the most common histopathological diagnosis in our study
followed by Crescentic GN (CSGN) 16(16.6%) and Mesangiocapillary GN (MPGN) 12(12.5%). Pauci-immune GN (PI)
was the most common cause of Crescentic GN; 7/16(43.75%), followed by Immune mediated GN; 2/16(12.5%).
Conclusion: Histopathological patterns of patients with clinically suspected RPGN is an integral part of investigation of
such patients both for diagnostic and prognostic purpose. Tubulo interstitial Nephritis turns out to be the most common
histopathological diagnosis in patients with clinical RPGN. As opposed to Crescentic GN in most studies.

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