POST OPERATIVE NAUSEA AND VOMITING IN AMBULATORY SURGERY: COMPARISON OF MIDAZOLAM WITH NORMAL SALINE
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Abstract
Objectives: To compare the efficacy of intra-venous midazolam for prevention of post-operative nausea and vomiting in comparison with normal saline (placebo) in ambulatory endoscopic procedures.
Material and Methods: This study was conducted at Department of Anesthesiology at Institute of Kidneys Diseases and Critical Care Hayatabad Medical Complex Peshawar on 70 patients of either sex, 35 in each group. Group A(n-35) received midazolam and Group B(n-35)Normal saline (placebo) prior to induction of general anesthesia. Only those patients were included who fulfilled our inclusion criteria and assessed for episodes of post-operative Nausea and vomiting at 1to 6 hours postoperatively. Study design was randomized controlled trial.
Results: During 1st post operative hour up to 66% patients in group “A” had complained for nausea and vomiting in which 40% patients had complained for nausea and 26% patients complained for vomiting. While 71% patients in group “B” had complained for nausea and vomiting in which 28% patients had complained for nausea and 43% patients complained for vomiting. Similarly after 6th hour 22% patients in group “A” had complained for nausea and vomiting in which 14% patients had complained for nausea and 8% patients complained for vomiting. While 48% in group “B” had complained for nausea and vomiting in which 20% patients had complained for nausea and 28% patients complained for vomiting.
Conclusion: We concluded that midazolam 50-75?gm/kg i/v preoperatively significantly decreases the incidence of nausea and vomiting in Patient undergoing ambulatory (day care) endoscopic procedures under general anesthesia.
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