6. PREVALENCE OF G6PD DEFICIENCY IN SCHOOL GOING ENROLLED CHILDREN IN DISTRICT MARDAN

Mohtasimbillah1, Sardar Ahmad2, Imtiaz Ahmad3, Hiba Khan1, Hifsa Gul1, Abid Sohail Taj4

1Department of Pathology, Bacha Khan Medical College Mardan - Pakistan
2Department of Pathology, Saidu Medical College, Swat - Pakistan
3Department of Pathology, BKMC Mardan - Pakistan
4Department of Pathology, IBMS Peshawar - Pakistan

Abstract

Objective: To find out prevalence of Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency in school going enrolled
children of District Mardan.
Material and Methods: The study was carried out in community based primary schools, where 400 male apparently
healthy children in the age range of 5-10 years with a mean age of 8.55 ± 1.23 yrs. were randomly selected. The activity
of G6PD was determined by a dye reduction method screening test devised by Sigma Diagnostics USA.
Results: The overall prevalence of G6PD deficiency in our study was 10%. Further analysis showed that distribution in
two tehsils of the district i.e., Tehsil Mardan was 8.5 % and in Tehsil Takhtbhai was 11.5 %.
Conclusion: Glucose 6 phosphate Dehydrogenase deficiency is one of the most commonly occurring congenital red cell
enzymopathy in our province. Being highly prevalent, community screening for early detection of susceptible cases will
not only prevent the development of hemolytic crises by avoiding oxidative stress but will also improve the quality of life.

Keywords: Glucose 6 phosphate Dehydrogenase Deficiency (G6PD), Oxidative stress

Download Full Pdf