Ubaid ur Rehaman, Sadaf Durrani, Ubaidullah, Sabia Ali, Muddassir Ahmad Khan, Saif Ur Rahman Wazir

Department of Biochemistry, Khyber Medical College, Peshawar - Pakistan


Objective: To see whether obesity decreases the testosterone concentration in young male adults, who have no other
cause of decreased testosterone.
Material & Methods: This was a comparative, case control and cross sectional study conducted in the Department
of Biochemistry, Khyber Medical College, Peshawar - Pakistan. The study period was from January 2016 to December
2016, consisting of two groups, A and B, each having 32 subjects. Group A had BMI of >25 Kg/m2 while the control
group B had BMI of < 25 Kg/m2. Their testosterone concentrations were compared keeping other confounding factors
like age, sex, educational status and socioeconomic conditions constant. The weight in Kg and height in meters were
measured for each subject and then BMI was calculated. A blood sample of approximately 5-ml was collected from
each participant. The sera were prepared and stored in labeled tubes which were then properly sealed, placed in racks
and were stored in a freezer at -20oC till further analysis. The samples were analyzed for serum Testosterone level by
Radioimmunoassay (RIA) method.
Results: Group A had 32 obese subjects having a BMI 26.9 Kg/m2 with a SD of 1.501. The testosterone concentration
of group A is compared with that of control group B having a normal BMI of 21.7 with a SD of 1.557. Testosterone concentrations
of the two study groups revealed a significant difference (P< 0.001) when compared by the independent
sample t-test.
Conclusion: The increase trend of obesity in elderly people and now in young adults should be prevented as it lower
serum testosterone concentrations, apart from other hazards like diabetes, hypertension, CVD and osteoarthritis.

Keywords: Testosterone, overweight, obesity, young adults

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