Wazir Mohammad Khan1, Abidullah Khan1, Majid Khan1, Maimoona Ayub1, Azer Rashid2

1Department of Medicine, Khyber Teaching Hospital, Peshawar - Pakistan
2Department of Dermatology, Khyber Teaching Hospital, Peshawar - Pakistan


Objective: To assess the association of uric acid with both, xanthelasma and the fasting blood lipids.
Material and Methods: This cross-sectional study was conducted in the Department of Medicine, Khyber Teaching
Hospital, Peshawar, Pakistan from January 2015 to July 2016 and included 60 cases with xanthelasma palpebrarum
(XP) as the study group, and 60 age and sex matched individuals without xanthelasma palpebrarum (WXP), as the
control group. Each participant had his/her fasting lipid profile determined, along with serum uric acid. The data was
analyzed using SPSS version 16. Independent t-test and Pearson correlation tests were applied.
Results: The values of uric acid, fasting total cholesterol, LDL-C and TGs were higher, and HDL-C lower, in the XP
group, than in WXP group, (P <0.001). Serum uric acid correlated positively with serum total cholesterol, triglycerides
and LDL-C (P <0.001), and negatively with HDL-C, (P < 0.001). Moreover, fasting cholesterol level was higher in XP
group (M=208.32, SD=17.135), than WXP group (M=177.28, SD=8.203), at a statistically significant level of, t (84.69)
=12.65, P <0.001, Cohen’s D=2.31.
Conclusion: Serum uric acid is higher in subjects with xanthelasmata. Moreover, serum uric acid has a positive correlation
with both; LDL-c and TGs, but an inverse relation with HDL-c

Keywords: xanthelasma palpebrarum, dyslipidemia, uric acid, atherosclerosis

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