9. ROLE OF ASYMMETRICAL DIMETHYL ARGININE IN CARDIOVASCULAR DIABETOLOGY

Kalsoom Tariq, Mudassir Ahmad Khan, Naheed Khattak

Department of Bio-Chemistry, Khyber Medical College, Peshawar - Pakistan

Abstract

Objective: To determine the serum ADMA level and association of different biochemical parameters with ADMA in
diabetes mellitus patients with and without coronary artery disease and normal healthy individuals.
Material and Methods: A total of 210 patients ,out of which 70 type 2 diabetics without coronary artery disease in
group B and 70 type 2 diabetics with CAD in group C are included. 70 normal control individuals in group A were also
enrolled in the study. Blood was obtained from each participant for biochemical analysis of fasting blood sugar (FBS),
glycated hemoglobin (HbA1c), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL),
triglyceride (TG) and asymmetrical dimethyl arginine (ADMA).
Results: An elevated ADMA was noted in diabetic subjects with and without coronary artery disease than the healthy
control group (03.9±1.5?mol/L and 02.0±0.6 Vs. 0.6±0.2 ?mol/L). Similarly different parameters like FBS, HbA1c, HDL,
LDL-C Triglyceride were found to be elevated in groupB and group C as compared to group A.
Conclusion: All biochemical parameters are found to be increased in both the diseased groups i.e type 2 diabetes
mellitus without CAD and type 2 diabetes mellitus with CAD as compared to the normal healthy individuals.

Keywords: Asymmetric dimethylarginine (ADMA),Type 2 diabetes mellitus,Coronary artery disease, Glycosylated hemoglobin, Lipid profile.

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