7. EFFICACY OF ONDANSETRON AND METOCLOPRAMIDE AGAINST POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

Muhammad Ilyas1, Neelum Noreen Halimi1, Rashid Waheed2, Shahana Salim1

1Department of Anesthesia, Khyber Teaching Hospital, Peshawar - Pakistan
2Department of Surgery, Khyber Teaching Hospital, Peshawar - Pakistan

Abstract

Objectives: Comparing the clinical efficacy of the antiemetics (Ondansetron and Metoclopramide) in preventing postoperative
nausea and vomiting (PONV) in patients undergoing Laparoscopic Cholecystectomy (LC).
Material and Methods: This is a randomised study conducted at anesthesiology department, Khyber Teaching Hospital,
Peshawar, Pakistan from April 2015 to December 2015. Two treatment arms Group A (Ondansetron) and B (Metoclopramide)
were created. A sample of 60 patients was selected in each treatment group.
Results: The overall mean age was 43.42 ± 10.8 years with 37 (30.8%) males and 83 (69.2%) females in a ratio of 1 to
2.24. Overall mean weight was 77.08 ± 9.05 Kg. Mean age in group A was 43.5 ± 10.8 years while it was 43.2 ± 10.9
years. Similarly, mean weight in group A was 76.5 ± 9.3 Kg while it was 77.6 ± 8.8 Kg. A Chi-squared test performed
for treatment group versus the incidence of PONV showed that PONV in group A was 13.3% while in group B it was
27.5% of the total episodes of PONV with a significant association of PONV with group B (p = 0.002). The early PONV
episodes occurred in significantly higher proportion in group B as compared to group A (15% group B versus 6.7%
in group A, p = 0.027). However, late PONV episodes were not significant for any treatment group (6.7% in group A
versus 13.3% in group B, p = 0.068).
Conclusion: Peri-induction use of intravenous ondansetron is an effective alternative than intravenous metoclopramide
in prevention of nausea/vomiting after LC.

Keywords: Nausea, vomiting, laparoscopic cholecystectomy, Ondansetron, Metoclopramide

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