HIGH RESISTANCE OF CIPROFLOXACIN AGAINST ESCHERICHIA COLI IN COMPLICATED URINARY TRACT INFECTION

Liaqat Ali, Khalid Farooq, Shafie Ullah Khan, Nasir Orakzai, Qudratullah

Department of Urology, Institute of Kidney Diseases, Hayatabad Medical Complex, Peshawar - Pakistan

Abstract

Objectives: To determine the risk factors for high resistance of ciprofloxacin against E. Coli in complicated urinary tract infections.

Material and Methods: It is an analytical study that was conducted in department of Urology (Team ‘C’) at Institute of Kidney Diseases Hayatabad Peshawar from 1st June 2012 till 31st December 2012. Total numbers of 100 patients with complicated UTI was selected in the study. Multivariate analysis and linear regression was performed for the detection of risk factors. All the data was recorded on structured Proforma and was analyzed on SPSS version 17.

Results: The mean age of the patient was 55.6 years (Range 3-82 years). Sixty-two patients were male while 38 patients were female. 66 isolates of E-Coli were found sensitive to ciprofloxacin while 34 isolates were found Resistant for ciprofloxacin. Using multivariate analysis and linear regression, an increasing age above 50 (p=0.002) History of urinary catheterization especially for bladder outflow obstruction (p=0.001) and previous multiple use of ciprofloxacin (p=0.001) and poor brand of ciprofloxacin were found to be independent risk factors for high resistance of ciprofloxacin.

Conclusion: The risk factors for emerging resistance are increasing age, urinary catheterization and multiple use and poor brand of ciprofloxacin

Keywords: Urinary tract, Infection, Ciprofloxacin, Urethral catheterization , Antimicrobial resistance

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